Lactium® is a unique, clinically researched bioactive casein hydrolysate containing a bioactive decapeptide (a polypeptide 10-chain amino acid alpha-1 sequence) developed to target stress-related symptoms. In a 30-day study, subjects who supplemented with 150 mg Lactium® daily reported statistically significant support for multiple stress-related effects, including digestion, mood, relaxation, sleep and cardiovascular and cognitive function. In studies where individuals or animals were exposed to mild stressors, supplementation helped moderate healthy heart rate and blood flow, as well as plasma cortisol. Cortisol is released by the adrenal glands during acute and chronic stress. In another study, Lactium® promoted the onset of sleep and healthy sleep quality. Healthy sleep quality has been associated with cognitive function and working memory. Sleep also has been tied to metabolic health, including mitochondrial function, visceral fat deposition, alterations in gut barrier function and changes in gut microbiota. Several studies have shown l-theanine to enhance alpha wave production in the occipital and parietal regions of the brain, helping calm the sympathetic nervous system for a relaxing effect without drowsiness. l-Theanine also helps maintain healthy IgA levels, suggesting support for immune health during occasional stress. Preclinical research suggests that vitamin D plays a role in promoting healthy immune and cardiometabolic biomarkers, and may support normal cortisol production within abdominal adipocytes at the cellular level. Vitamin D may be particularly important for individuals with certain genetic variations.