Joint Complex (single dose) contains UC-II® undenatured type-II collagen complex, hyaluronic acid and MSM to support joint health, flexibility, and comfort. In a randomized, double-blind trial involving 52 subjects, 40 mg of UC-II® was more than twice as effective in promoting joint health as 1,500 mg of glucosamine and 1,200 mg of chondroitin as rated by WOMAC, VAS, and the Lequesne functional index. Another study involving five women supplemented with 40 mg of UC-II® for 42 days, indicated statistically significant support for joint comfort and flexibility. MSM provides sulfur to enhance the structure and integrity of proteoglycans. A randomized, double-blind, placebo-controlled trial indicates that MSM promotes joint comfort and function. Research suggests that MSM may also support antioxidant capacity during exercise. Hyaluronic acid helps maintain tissue hydration to support joint lubrication. HyaMax® sodium hyaluronate provides a low molecular weight source of hyaluronic acid produced through fermentation. In a pharmacokinetic study, orally administered HyaMax® hyaluronic acid was incorporated into joints, connective tissue, and skin, with a particular affinity for cartilaginous joints. Lastly, 5-LOXIN® AKBA boswellia and enhanced absorption Meriva® turmeric extracts help maintain healthy 5-lipoxygenase and cyclooxygenase-2 enzyme activity and cytokine metabolism to offer additional joint comfort support.